In today's dynamic realm of mental health, the upswing of Post-Traumatic Stress Disorder (PTSD) has necessitated a radical shift in the way treatment centers approach therapy and healing. As we stand at the precipice of a new era, it becomes salient to explore what the future holds for these centers. This involves delving into predictions and forthcoming trends that could potentially redefine the contours of PTSD treatment.

PTSD, a debilitating mental health condition, often manifests in individuals who have experienced a traumatic event. These events could range from war combat to sexual assault or even natural disasters. Those affected may struggle with recurrent, distressing memories of the trauma, leading to a plethora of emotional, cognitive, and behavioral disturbances.

Recent advances in technology and therapeutic methodologies, coupled with a better understanding of the human brain and its responses to trauma, are catalysts to the transformations in the PTSD treatment landscape. The gravity of the situation is underscored by the fact that according to the American Psychiatric Association, approximately 3.5% of U.S adults suffer from PTSD.

Traditionally, PTSD treatment centers have employed a blend of medication and psychotherapy. However, the advent of technology has begun to recalibrate this model. Virtual Reality Exposure Therapy (VRET), for instance, is an emerging trend. It utilizes immersive technology to recreate the traumatic event, allowing the individual to confront and gradually desensitize themselves to their trauma in a controlled environment. While it’s a promising and innovative approach, it’s important to be cognizant of the potential ethical issues surrounding VRET, such as the level of graphic detail and the need for informed consent.

Another frontier in PTSD treatment is the integration of artificial intelligence (AI). AI algorithms can analyze patterns and predict potential PTSD cases based on individual genetic predispositions and environmental influences. This predictive capability could enable preemptive measures, reducing the severity or even circumventing the onset of PTSD in susceptible individuals. However, the trade-off is the potential breach of privacy and security associated with data handling, which necessitates stringent protocols.

Stemming from a completely different angle, the burgeoning field of psychedelic-assisted therapy provides a novel approach. In recent studies, drugs such as MDMA and psilocybin have shown promise in aiding the therapeutic process for PTSD sufferers, allowing them to access and process traumatic memories more effectively. However, the contentious history and legal status of these substances necessitate rigorous, empirical research before they can be leveraged as mainstream treatment options.

Similarly, the concept of trauma-informed care is gaining traction. This approach emphasizes understanding, recognizing, and responding to the effects of all types of trauma. It underlines the importance of creating a safe environment for individuals with PTSD, a fundamental tenet that sometimes eludes traditional treatment paradigms.

Lastly, we must consider the potential landscape-altering impact of epigenetic research in PTSD treatment. Epigenetics, the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself, could potentially unlock the ability to identify individuals genetically predisposed to PTSD. While this is an exciting prospect, it opens a Pandora's box of ethical questions around genetic profiling and discrimination.

Looking ahead, it is reasonable to anticipate a dramatic evolution in PTSD treatment centers. However, it is critical that these advancements are driven by empathy, patient autonomy, and a deep understanding of ethical implications. All new technologies and methodologies need to serve not just as tools for clinical utility, but also as conduits for humane, compassionate care. It will be through this careful amalgamation of progress and perspective that the future of PTSD treatment centers will be realized.